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Table 1 Description of included randomized controlled trials

From: Treatment with lamivudine versus lamivudine and thymosin alpha-1 for e antigen-positive chronic hepatitis B patients: a meta-analysis

Author

Sample size (C/M)

Therapy period

Virological end-point

Follow-up period(m)

Study design

Grade

Lee 2008

62(31/31)

Tα1 24w+LAM 52w

HBV DNA(-)

0

RCT

B

Li 2005

68(34/34)

Tα1 52w+LAM 52w

HBV DNA(-)

0

RCT

C

Liang 2006

72(36/36)

Tα1 6m+LAM 12m

HBV DNA(-)

12

RCT

B

Lin 2003

72(35/37)

Tα1 26w+LAM 52w

HBV DNA(-)

12

RCT

B

Liu 2005

98(49/49)

Tα1 26w+LAM52w

HBV DNA(-)

0

RCT

C

Sun 2008

81(41/40)

Tα1 6m+LAM12m

HBV DNA(-)

12

RCT

C

Wu 2002

60(29/31)

Tα1 6m+LAM12m

HBV DNA(-)

12

RCT

B

Zhao 2007

68(33/35)

Tα1 6m+LAM12-18m

HBV DNA(-)

0

RCT

C

  1. Abbreviations C: combination therapy; M: monotherapy; Tα1: thymosin alpha 1; LAM: lamivudine; w: weeks; m: months; RCT: randomized controlled trail.