Figure 5
Melting pot rolling circle replication model. i. Replication origin representation after binding of the Rep. Strands (+) and (-) are close together. The destabilized environment known as "melting pot" is included in the dotted oval. ii. Schematic representation of the template DNA strands during the initiation of DNA synthesis. The leading strand shifts strand 'a', and uses strands 'a' and 'b' as template DNA strands. iii. Schematic representation of the template DNA strands at the termination of DNA synthesis. The leading strand shifts strand 'b' and uses either the newly synthesized 'aN ' or strand 'b'. Black: positive polarized genome (+); Blue: negative strand; Red: potential base pairs representation. Reprinted from Journal of Virology 78(8), Cheung AK, "Detection of template strand switching during initiation and termination of DNA replication of porcine circovirus." pages 4268–4277, Copyright© 2004 [6], with permission from American Society for Microbiology.