Figure 2
Rolling circle replication model of single strand viruses. Black strand: positive parental strand and viral genome. Blue strand: negative lagging strand. Red strand: positive leading strand. a and b: the conversion of the single strand viral genome in the double strand DNA replicative intermediate is produced in the cell. c and d: REP complex binds to the stem-loop structure which is the origin of replication and initiates the replication by nicking the DNA. d and e: cellular DNA polymerase initiates viral DNA replication from the free 3'OH extremity and the REP complex still binds the 5' extremity. f and g: after a round of replication, the REP complex closes the DNA and releases a single strand DNA and a double strand DNA. h', h" and h"': DNA can be used for replication or can be encapsidated.