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Table 2 Neutralising antibody titers and outcome after challenge after DNA vaccination against RVFV

From: Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs

Vaccine group

No. of animals

PRNT50 titersa

Challenge dose

Outcome after challenge with RVFV

    

Asymptomatic

Clinical signsb

Deathsc

N

4

< 25

2.4 × 103

1

3

 
 

4

< 25

2.4 × 104

3

 

1

GN/GC

4

25 – 75

2.4 × 103

2

2

 
 

4

25 – 75

2.4 × 104

3

1

 

Ctrl/PUU-N

4

-

2.4 × 103

 

3

1

 

4

-

2.4 × 104

 

3

1

Ctrl/pcDNA3.1

3

-

2.4 × 103

 

3

 
 

3

-

2.4 × 104

 

3

 
  1. aVirus neutralising antibody titers after vaccination.
  2. bNumber of animals displaying clinical signs (ruffled fur/shivering), followed by complete recovery.
  3. cNumber of animals displaying a moribund condition (fatigue/"hunchback-like posture") followed by euthanization.
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Virology Journal

ISSN: 1743-422X