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Figure 6 | Virology Journal

Figure 6

From: Incorporation of membrane-bound, mammalian-derived immunomodulatory proteins into influenza whole virus vaccines boosts immunogenicity and protection against lethal challenge

Figure 6

Inactivated influenza vaccines bearing membrane-bound immunomodulators enhance serum anti-viral antibody titers. Balb/c mice were vaccinated subcutaneously with 0.375 μg of A/PR/8/34 wild-type (n = 20) or A/PR/8/34 bearing membrane-bound GM-CSF (n = 10), IL-2 (n = 19), and IL-4 (n = 20). PBS served as negative vehicle control. Serum was collected on day 21 post-vaccination and antibody titers for influenza virus specific IgG and isotypes IgG1 (Th2) and IgG2a (Th1) were determined by ELISA. Data is displayed as the geometric mean titer in ng/ml for each group. (* p < 0.05 compared to PR/8/34 w.t., ** p < 0.01 compared to PR/8/34 w.t.)

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Virology Journal

ISSN: 1743-422X