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Table 3 Minimal oligosaccharides bound by recent H3N2 viruses

From: Deletions of neuraminidase and resistance to oseltamivir may be a consequence of restricted receptor specificity in recent H3N2 influenza viruses

Virus

Minimal binding motifs

A/OK/323/03 (Fujian-like)1

Neu5Acα2–6Galβ1–4GlcNAc

Neu5Acα2–6GalNAcβ1–4GlcNAc

A/OK/1992/05 (California-like)1

Neu5Acα2–6Galβ1–4GlcNAc

Neu5Acα2–6GalNAcβ1–4GlcNAc

A/OK/309/06 (Wisconsin-like)

Neu5Acα2–6Galβ1–4GlcNAc

Neu5Acα2–6GalNAcβ1–4GlcNAc

9OAcNeu5Acα2–6Galβ1–4GlcNAc

Neu5Acα2–6GalNAc in any context

A/OK/483/08 (Brisbane-like)

Neu5Acα2–6Galβ1–4GlcNAcβ1–3Galβ1–4GlcNAc

  1. 1Data previously reported [9]