Figure 2
From: Modeling gene sequences over time in 2009 H1N1 Influenza A Virus populations
Mapping of naturally occurring amino acid substitutions in a NA protein 3D structure. The 3D structure model of the NA protein from 2009 H1N1 IAV shown in the figure was obtained by Mauer-Stroh et al. [27] (Bioinformatic Institute, A*STAR's Biomedical Sciences Institutes, Singapore). Oseltamivir atoms are shown in red. Antibodies binding sites are shown in green. Position 275, where substitution H275Y confers resistance to Oseltamivir, is shown in pink. The substitutions found among strains isolated during 30, 60, 90 (where viruses with H275Y substitution also arise) and 119 days (from March 30th, 2009) are shown in yellow, blue, orange and white in A through D, respectively. Dotted white lines show distances in Å.