Figure 7
In vivo Antiviral Dose Effect of REP 9C following Intraperitoneal or Oral Dosing. (a) Virus titer levels in the livers from mice treated with various doses of REP 9C. Three-week old mice (8 mice/group) were treated by daily i.p. administration of saline or 10 mg/kg (QD), 5 mg/kg (BID), 3 mg/kg (BID), 2 mg/kg (BID), or 0.5 mg/kg (BID) of REP 9C starting at 8 days prior to infection with MCMV and continued for 11 days. Data represents results from one of two separate experiments; Mean +/- standard deviation (n = 8). (b) Virus titer levels in the livers from mice treated orally with 100 mg sodium caprate (C10), 20 mg/kg REP 9C, 400 mg/kg REP 9C in 100 mg C10, and 400 mg/kg REP 9C in 0.25% (w/v) TDM. Five-week old mice (8 mice/group) were treated by daily oral administration of C10 or REP 9C + C10 or TDM starting 2 days prior to i.p. inoculation with 1 × 105 pfu of MCMV (K181+) and continued to 3 days post infection. Data represents results from one of two separate experiments with similar outcomes; mean +/- standard error (n = 8). The asterisk indicates groups in which mice died due to non-drug related technical difficulties with oral administration. In (a) and (b), mice with no detectable MCMV titer are indicated as x negative/8 total below each bar. P values are shown in figure.