In vivo Antiviral Comparison of REP 9C and Ganciclovir. Virus titer levels in the spleens (a) and livers (b) from mice treated with 10 or 20 mg/kg REP 9C or 50 mg/kg Ganciclovir (GCV). Five week old mice (8 mice/group) were treated by daily i.p. administration of saline, REP 9C or GCV starting at 2 days prior to i.p. inoculation with 1 × 105 pfu of MCMV (K181+) and continued for 3 days. Data represents results from one experiment; mean +/- standard deviation (n = 8). When observed, animals in each treatment group with no detectable CMV titer are indicated as x negative/8 total below each bar. P values are shown in figure.