Comparison of In vivo Antiviral Activity of REP 9 and REP 9C. Virus titer levels in the spleens (a) and livers (b) and spleen weights (c) are shown for mice treated with 10 mg/kg REP 9 or REP 9C. Five-week old mice (8 mice/group) were treated by daily i.p. administration of saline, REP 9, or REP 9C starting 2 days prior to i.p. inoculation with 1 × 105 pfu of MCMV (K181+) and continued to 3 days post infection. Data represents results from three separate experiments; Mean +/- standard error (n = 8/experiment). When observed, animals in each treatment group with no detectable MCMV titer are indicated as x negative/8 total below each bar. P values are shown in figure.