Antiviral Effects of REP 9 in the Spleen Following Different Routes of Administration. Viral titers in the spleen (a) and spleen weights (b) of mice treated with either GCV or REP 9 are shown. Five week old mice (8 mice/group) were treated daily with saline or REP 9 starting 2 days prior to i.v. inoculation with 1 × 103 pfu of MCMV (Smith) and continued until 3 days post infection. REP 9 was administered by i.v, i.p. or s.c. route of injection at 1 mg/kg, 10 mg/kg, or 20 mg/kg. As a control, 25 mg/kg GCV was administered by i.v. route of injection. Data represents results from one experiment; mean +/- standard deviation (n = 8). P values are shown in figure.