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Figure 9 | Virology Journal

Figure 9

From: The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques

Figure 9

Expression of RV2 ORF59 in the skin of a pig-tailed macaque naturally infected with the MneRV2 rhadinovirus and simian retrovirus-2 (SRV-2). Formalin-fixed skin tissue from (A) a juvenile (MneRV2 and SRV-2 negative) and (B) an adult (MneRV2 and SRV-2 positive) pig-tailed macaque from the WaNPRC was reacted with the 425 rabbit anti-RV2 ORF59 antiserum as described in Materials and Methods. A magnification of a section of the tissue in B (large arrowhead) is shown in (C). The different layers of the epidermal tissue are indicated. The vertically-oriented cells in the basal layer correspond to the undifferentiated, proliferating, columnar basal keratinocytes. The round cells present in the spinous layer and the flattened cells present in the granular layer correspond to the post-mitotic suprabasal keratinocytes.

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