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Table 7 Expression of genes involved with complement and coagulation cascades in LCMV-WE-infected macaque liver

From: Gene expression in primate liver during viral hemorrhagic fever

    Pre-viremic Viremic
GenBank Accession no. Symbol Gene description Fold changea pb Fold changea p b
NM_000014 A2M Alpha-2-macroglobulin 3.31 0.0219 2.71 0.0417
NM_000491 C1QB Complement component 1, q subcomponent, B chain 3.65 0.1140 12.2 0.0029
AI184968 C1QC Complement component 1, q subcomponent, C chain 1.47 0.5402 3.27 0.0140
AL573058 C1R Complement component 1, r subcomponent 2.20 0.0287 2.73 0.0054
BC007010 C1S Complement component 1, s subcomponent 53.44 0.0006 50.21 0.0004
NM_000592 C4A/C4B Complement component 4A (Rodgers blood group)///complement component 4B (Childo blood group) 5.20 0.0002 6.32 0.0001
NM_000716 C4BPB Complement component 4 binding protein, beta 3.22 0.0401 5.65 0.0032
NM_001735 C5 Complement component 5 8.75 0.0015 7.83 0.0013
J05064 C6 Complement component 6 3.24 0.0332 2.63 0.0624
NM_000587 C7 Complement component 7 2.34 0.1850 4.28 0.0152
M17263 C8G Complement component 8, gamma polypeptide 4.72 0.0051 4.56 0.0038
AL570661 CD46 CD46 molecule, complement regulatory protein 4.72 0.0015 3.24 0.0060
X04697 CFH Complement factor H 2.90 0.0124 2.86 0.0091
NM_000506 F2 Coagulation factor II (thrombin) 2.11 0.0329 1.65 0.1360
AA910306 F5 Coagulation factor V (proaccelerin, labile factor) 3.16 0.0218 2.47 0.0071
NM_000504 F10 Coagulation factor X 2.42 0.0070 1.85 0.0513
NM_000128 F11 Coagulation factor XI (plasma thromboplastin antecedent) -2.28 0.0150 -2.75 0.0029
NM_021871 FGA Fibrinogen alpha chain 3.86 0.0035 3.48 0.0039
BG545288 FGB Fibrinogen beta chain 49.86 0.0001 45.56 0.0001
NM_000509 FGG Fibrinogen gamma chain 2.67 0.0355 2.56 0.0325
M74220 LPA/PLG Lipoprotein, Lp(a)///plasminogen 4.69 0.0256 3.81 0.0396
NM_000892 KLKB1 Kallikrein B, plasma (Fletcher factor) 1 -1.70 0.1730 -2.32 0.0207
AI274095 MASP1 Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 3.07 0.0004 2.78 0.0005
AB008047 MASP2 Mannan-binding lectin serine peptidase 2 4.75 0.0144 3.16 0.0489
NM_000242 MBL2 Mannose-binding lectin (protein C) 2, soluble (opsonic defect) 3.18 0.0162 1.37 0.5910
BE880828 MCFD2 Multiple coagulation factor deficiency 2 11.71 0.0004 14.72 0.0001
M74220 PLG Plasminogen 3.86 0.0059 3.60 0.0054
NM_000295 SERPINA1 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), 1 8.20 0.0003 7.21 0.0004
BC022309 SERPINC1 Serpin peptidase inhibitor, clade C (antithrombin), member 1 30.65 0.0005 19.29 0.0009
NM_000062 SERPING1 Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 2.77 0.0336 3.07 0.0296
BF511231 TFPI Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.05 0.0312 1.45 0.2590
  1. a Mean fold changes were calculated using a division of raw expression values between experimental sample and uninfected control.
  2. b All samples were analyzed separately. Changes in gene expression with a cutoff of 2.0-fold increased or decreased expression was used and, the p-value was calculated by Student's t-test. Data are displayed only where the, p ≤ 0.05. This p-value was used as a measure of the magnitude of the difference between groups and to determine significance of the modulation. The modulated genes in the pathway are listed in alphabetic order.