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Table 7 Expression of genes involved with complement and coagulation cascades in LCMV-WE-infected macaque liver

From: Gene expression in primate liver during viral hemorrhagic fever

   

Pre-viremic

Viremic

GenBank Accession no.

Symbol

Gene description

Fold changea

pb

Fold changea

p b

NM_000014

A2M

Alpha-2-macroglobulin

3.31

0.0219

2.71

0.0417

NM_000491

C1QB

Complement component 1, q subcomponent, B chain

3.65

0.1140

12.2

0.0029

AI184968

C1QC

Complement component 1, q subcomponent, C chain

1.47

0.5402

3.27

0.0140

AL573058

C1R

Complement component 1, r subcomponent

2.20

0.0287

2.73

0.0054

BC007010

C1S

Complement component 1, s subcomponent

53.44

0.0006

50.21

0.0004

NM_000592

C4A/C4B

Complement component 4A (Rodgers blood group)///complement component 4B (Childo blood group)

5.20

0.0002

6.32

0.0001

NM_000716

C4BPB

Complement component 4 binding protein, beta

3.22

0.0401

5.65

0.0032

NM_001735

C5

Complement component 5

8.75

0.0015

7.83

0.0013

J05064

C6

Complement component 6

3.24

0.0332

2.63

0.0624

NM_000587

C7

Complement component 7

2.34

0.1850

4.28

0.0152

M17263

C8G

Complement component 8, gamma polypeptide

4.72

0.0051

4.56

0.0038

AL570661

CD46

CD46 molecule, complement regulatory protein

4.72

0.0015

3.24

0.0060

X04697

CFH

Complement factor H

2.90

0.0124

2.86

0.0091

NM_000506

F2

Coagulation factor II (thrombin)

2.11

0.0329

1.65

0.1360

AA910306

F5

Coagulation factor V (proaccelerin, labile factor)

3.16

0.0218

2.47

0.0071

NM_000504

F10

Coagulation factor X

2.42

0.0070

1.85

0.0513

NM_000128

F11

Coagulation factor XI (plasma thromboplastin antecedent)

-2.28

0.0150

-2.75

0.0029

NM_021871

FGA

Fibrinogen alpha chain

3.86

0.0035

3.48

0.0039

BG545288

FGB

Fibrinogen beta chain

49.86

0.0001

45.56

0.0001

NM_000509

FGG

Fibrinogen gamma chain

2.67

0.0355

2.56

0.0325

M74220

LPA/PLG

Lipoprotein, Lp(a)///plasminogen

4.69

0.0256

3.81

0.0396

NM_000892

KLKB1

Kallikrein B, plasma (Fletcher factor) 1

-1.70

0.1730

-2.32

0.0207

AI274095

MASP1

Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)

3.07

0.0004

2.78

0.0005

AB008047

MASP2

Mannan-binding lectin serine peptidase 2

4.75

0.0144

3.16

0.0489

NM_000242

MBL2

Mannose-binding lectin (protein C) 2, soluble (opsonic defect)

3.18

0.0162

1.37

0.5910

BE880828

MCFD2

Multiple coagulation factor deficiency 2

11.71

0.0004

14.72

0.0001

M74220

PLG

Plasminogen

3.86

0.0059

3.60

0.0054

NM_000295

SERPINA1

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), 1

8.20

0.0003

7.21

0.0004

BC022309

SERPINC1

Serpin peptidase inhibitor, clade C (antithrombin), member 1

30.65

0.0005

19.29

0.0009

NM_000062

SERPING1

Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

2.77

0.0336

3.07

0.0296

BF511231

TFPI

Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

2.05

0.0312

1.45

0.2590

  1. a Mean fold changes were calculated using a division of raw expression values between experimental sample and uninfected control.
  2. b All samples were analyzed separately. Changes in gene expression with a cutoff of 2.0-fold increased or decreased expression was used and, the p-value was calculated by Student's t-test. Data are displayed only where the, p ≤ 0.05. This p-value was used as a measure of the magnitude of the difference between groups and to determine significance of the modulation. The modulated genes in the pathway are listed in alphabetic order.
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Virology Journal

ISSN: 1743-422X