Gene expression in primate liver during viral hemorrhagic fever

Table 6 Expression of various lipase genes and genes involved with lipase activity in LCMV-WE infected macaque liver.

			Pre-viremic		Viremic
GenBank Accession no	Symbol	Gene description	Fold change^a	p ^b	Fold change^a	p ^b
NM_000483	APOC2	Apolipoprotein C-II	5.50	0.0003	3.53	0.0019
AK023348	GRN	Granulin	1.84	0.0448	3.20	0.0007
NM_006854	KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	7.46	0.0056	7.36	0.0038
NM_000235	LIPA	Lipase A, lysosomal acid, cholesterol esterase	2.17	0.1350	4.08	0.0059
NM_006033	LIPG	Lipase, endothelial	2.20	0.4480	2.55	0.2950
AF077198	LYPLA1	Lysophospholipase I	7.16	0.0006	3.81	0.0008
BC006230	MGLL	Monoglyceride lipase	3.27	0.0090	2.73	0.0162
D83485	PDIA3	Protein disulfide isomerase family A, member 3	6.36	0.0028	7.46	0.0010
AL542253	PLA1A	Phospholipase A1 member A	1.37	0.0035	3.01	0.0124
NM_000300	PLA2G2A	Phospholipase A2, group IIA (platelets)	2.19	0.7700	26.17	0.0218
AF145020	PLAA	Phospholipase A2-activating protein	3.51	0.0026	2.69	0.0077
NM_002937	RNASE4	Ribonuclease, RNase A family, 4	45.25	0.00008	25.81	0.0001

^a Mean fold changes were calculated using a division of raw expression values between experimental sample and uninfected control.
^b All samples were analyzed separately. Changes in gene expression with a cutoff of 2.0-fold increased or decreased expression was used and, the p-value was calculated by Student's t-test. Data are displayed only where the, p ≤ 0.05. This p-value was used as a measure of the magnitude of the difference between groups and to determine significance of the modulation. The modulated genes in the pathway are listed in alphabetic order.

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