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Table 5 Expression of genes involved with fatty acid, cholesterol and amino acid metabolism in LCMV-WE infected macaque liver.

From: Gene expression in primate liver during viral hemorrhagic fever

    Pre-viremic Viremic
GenBank Accession no. Symbol Gene description Fold changea p b Fold changea p b
Fatty acid metabolism
AI057637 ACACB Acetyl-Coenzyme A carboxylase beta -3.58 0.0103 -4.38 0.0027
NM_001096 ACLY ATP citrate lyase 2.14 0.0809 3.58 0.0040
AB032261 SCD Stearoyl-CoA desaturase (delta-9-desaturase) 2.06 0.0448 4.69 0.0420
Cholesterol metabolism
BC000408 ACAT2 Acetyl-CoA acetyltransferase 2 (acetoacetyl CoA thiolase) 6.10 0.0065 4.78 0.0107
U40053 CYP51A1 Cytochrome P450, family 51, subfamily A, polypeptide 1 3.68 0.0622 12.04 0.0010
NM_014762 DHCR24 24-dehydrocholesterol reductase 5.28 0.0006 3.66 0.0021
BC003573 FDFT1 Farnesyl-diphosphate farnesyltransferase 1 5.70 0.0195 6.02 0.0011
NM_002004 FDPS Farnesyl diphosphate synthase 3.63 0.0218 5.03 0.0040
BG035985 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 3.01 0.0198 4.69 0.0467
NM_005336 HDLBP High density lipoprotein binding protein (vigilin) 4.96 0.0007 3.14 0.0042
AF478446 NR1H4 Nuclear receptor subfamily 1, group H, member 4 11.31 0.0003 10.48 0.0002
BF530535 SPCS2 Signal peptidase complex subunit 2 10.34 0.0009 8.28 0.0011
Amino acid metabolism
NM_000687 AHCY S-adenosylhomocysteine hydrolase 7.46 0.0005 4.03 0.0048
AF110329 GLS2 Glutaminase 2 30.06 0.0039 11.31 0.0201
NM_002080 GOT2 Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 4.53 0.0036 3.12 0.0140
NM_000531 OTC Ornithine carbamoyltransferase 4.47 0.0182 2.58 0.1090
  1. a Mean fold changes were calculated using a division of raw expression values between experimental sample and uninfected control.
  2. b All samples were analyzed separately. Changes in gene expression with a cutoff of 2.0-fold increased or decreased expression was used and, the p-value was calculated by Student's t-test. Data are displayed only where the, p ≤ 0.05. This p-value was used as a measure of the magnitude of the difference between groups and to determine significance of the modulation. The modulated genes in the pathway are listed in alphabetic order.