Gene expression in primate liver during viral hemorrhagic fever

Table 5 Expression of genes involved with fatty acid, cholesterol and amino acid metabolism in LCMV-WE infected macaque liver.

			Pre-viremic		Viremic
GenBank Accession no.	Symbol	Gene description	Fold change^a	p ^b	Fold change^a	p ^b
*Fatty acid metabolism*
AI057637	ACACB	Acetyl-Coenzyme A carboxylase beta	-3.58	0.0103	-4.38	0.0027
NM_001096	ACLY	ATP citrate lyase	2.14	0.0809	3.58	0.0040
AB032261	SCD	Stearoyl-CoA desaturase (delta-9-desaturase)	2.06	0.0448	4.69	0.0420
*Cholesterol metabolism*
BC000408	ACAT2	Acetyl-CoA acetyltransferase 2 (acetoacetyl CoA thiolase)	6.10	0.0065	4.78	0.0107
U40053	CYP51A1	Cytochrome P450, family 51, subfamily A, polypeptide 1	3.68	0.0622	12.04	0.0010
NM_014762	DHCR24	24-dehydrocholesterol reductase	5.28	0.0006	3.66	0.0021
BC003573	FDFT1	Farnesyl-diphosphate farnesyltransferase 1	5.70	0.0195	6.02	0.0011
NM_002004	FDPS	Farnesyl diphosphate synthase	3.63	0.0218	5.03	0.0040
BG035985	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	3.01	0.0198	4.69	0.0467
NM_005336	HDLBP	High density lipoprotein binding protein (vigilin)	4.96	0.0007	3.14	0.0042
AF478446	NR1H4	Nuclear receptor subfamily 1, group H, member 4	11.31	0.0003	10.48	0.0002
BF530535	SPCS2	Signal peptidase complex subunit 2	10.34	0.0009	8.28	0.0011
*Amino acid metabolism*
NM_000687	AHCY	S-adenosylhomocysteine hydrolase	7.46	0.0005	4.03	0.0048
AF110329	GLS2	Glutaminase 2	30.06	0.0039	11.31	0.0201
NM_002080	GOT2	Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	4.53	0.0036	3.12	0.0140
NM_000531	OTC	Ornithine carbamoyltransferase	4.47	0.0182	2.58	0.1090

^a Mean fold changes were calculated using a division of raw expression values between experimental sample and uninfected control.
^b All samples were analyzed separately. Changes in gene expression with a cutoff of 2.0-fold increased or decreased expression was used and, the p-value was calculated by Student's t-test. Data are displayed only where the, p ≤ 0.05. This p-value was used as a measure of the magnitude of the difference between groups and to determine significance of the modulation. The modulated genes in the pathway are listed in alphabetic order.

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