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Table 4 Expression of genes involved with fatty acid oxidation in LCMV-WE infected macaque liver

From: Gene expression in primate liver during viral hemorrhagic fever

    Pre-viremic Viremic
GenBank Accession no. Symbol Gene description Fold changea p b Fold changea p b
Mitochondrial {beta}-oxidation
BE897866 ACADSB Acyl-CoA dehydrogenase, short/branched chain 1.77 0.6240 -2.93 0.0190
NM_004453 ETFDH Electron-transferring flavoprotein dehydrogenase 3.10 0.0019 1.49 0.1412
NM_004092 ECHS1 Enoyl CoA hydratase, short chain, 1, mitochondrial 7.06 0.0110 4.79 0.0260
U04627 HADHA Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha 3.43 0.0180 3.75 0.0086
Microsomal oxidation
AF182275 CYP2A6 Cytochrome P450, family 2, subfamily A, polypeptide 6 17.88 0.0008 7.21 0.0009
X06399 CYP2B6 Cytochrome P450, family 2, subfamily B, polypeptide 6 3.16 0.0079 -1.02 0.9980
NM_030878 CYP2C8 Cytochrome P450, family 2, subfamily C, polypeptide 8 3.51 0.0020 2.35 0.0147
NM_000106 CYP2D6 Cytochrome P450, family 2, subfamily D, polypeptide 6 7.78 0.0065 2.66 0.1530
AF182276 CYP2E1 Cytochrome P450, family 2, subfamily E, polypeptide 1 4.06 0.0150 2.87 0.0459
NM_000777 CYP3A5 Cytochrome P450, family 3, subfamily A, polypeptide 5 7.57 0.0005 6.36 0.0005
AF315325 CYP3A7 Cytochrome P450, family 3, subfamily A, polypeptide 7 11.39 0.0006 5.28 0.0050
Ketogenesis
BC000408 ACAT2 Acetyl-CoA acetyltransferase 2 (acetoacetyl CoA thiolase) 6.10 0.0065 4.78 0.0107
BG035985 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 3.10 0.0198 4.69 0.0467
NM_005518 HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 5.16 0.0135 2.91 0.0748
BF224073 TCP1 T-complex 1 3.43 0.0332 2.50 0.0977
Peroxisomal oxidation
NM_003500 ACOX2 Acyl-CoA oxidase 2, branched chain 6.63 0.0019 3.12 0.0267
NM_004092 ECHS1 Enoyl CoA hydratase, short chain, 1, mitochondrial 7.06 0.0110 4.79 0.0260
U04627 HADHA Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha 3.43 0.0180 3.75 0.0086
NM_005525 HSD11B1 Hydroxysteroid (11-beta) dehydrogenase 1 2.80 0.0325 2.20 0.0874
AL031228 HSD17B8 Hydroxysteroid (17-beta) dehydrogenase 8 2.80 0.0258 2.20 0.0620
Other peroxisomal proteins
AU147084 CAT Catalase 8.63 0.0028 5.78 0.0069
Others
NM_000072 CD36 CD36 molecule (thrombospondin receptor) 48.18 0.0001 16.11 0.0008
  1. a Mean fold changes were calculated using a division of raw expression values between experimental sample and uninfected control.
  2. b All samples were analyzed separately. Changes in gene expression with a cutoff of 2.0-fold increased or decreased expression was used and, the p-value was calculated by Student's t-test. Data are displayed only where the, p ≤ 0.05. This p-value was used as a measure of the magnitude of the difference between groups and to determine significance of the modulation. The modulated genes in the pathway are listed in alphabetic order.