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Table 4 Expression of genes involved with fatty acid oxidation in LCMV-WE infected macaque liver

From: Gene expression in primate liver during viral hemorrhagic fever

   

Pre-viremic

Viremic

GenBank Accession no.

Symbol

Gene description

Fold changea

p b

Fold changea

p b

Mitochondrial {beta}-oxidation

BE897866

ACADSB

Acyl-CoA dehydrogenase, short/branched chain

1.77

0.6240

-2.93

0.0190

NM_004453

ETFDH

Electron-transferring flavoprotein dehydrogenase

3.10

0.0019

1.49

0.1412

NM_004092

ECHS1

Enoyl CoA hydratase, short chain, 1, mitochondrial

7.06

0.0110

4.79

0.0260

U04627

HADHA

Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha

3.43

0.0180

3.75

0.0086

Microsomal oxidation

AF182275

CYP2A6

Cytochrome P450, family 2, subfamily A, polypeptide 6

17.88

0.0008

7.21

0.0009

X06399

CYP2B6

Cytochrome P450, family 2, subfamily B, polypeptide 6

3.16

0.0079

-1.02

0.9980

NM_030878

CYP2C8

Cytochrome P450, family 2, subfamily C, polypeptide 8

3.51

0.0020

2.35

0.0147

NM_000106

CYP2D6

Cytochrome P450, family 2, subfamily D, polypeptide 6

7.78

0.0065

2.66

0.1530

AF182276

CYP2E1

Cytochrome P450, family 2, subfamily E, polypeptide 1

4.06

0.0150

2.87

0.0459

NM_000777

CYP3A5

Cytochrome P450, family 3, subfamily A, polypeptide 5

7.57

0.0005

6.36

0.0005

AF315325

CYP3A7

Cytochrome P450, family 3, subfamily A, polypeptide 7

11.39

0.0006

5.28

0.0050

Ketogenesis

BC000408

ACAT2

Acetyl-CoA acetyltransferase 2 (acetoacetyl CoA thiolase)

6.10

0.0065

4.78

0.0107

BG035985

HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

3.10

0.0198

4.69

0.0467

NM_005518

HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

5.16

0.0135

2.91

0.0748

BF224073

TCP1

T-complex 1

3.43

0.0332

2.50

0.0977

Peroxisomal oxidation

NM_003500

ACOX2

Acyl-CoA oxidase 2, branched chain

6.63

0.0019

3.12

0.0267

NM_004092

ECHS1

Enoyl CoA hydratase, short chain, 1, mitochondrial

7.06

0.0110

4.79

0.0260

U04627

HADHA

Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha

3.43

0.0180

3.75

0.0086

NM_005525

HSD11B1

Hydroxysteroid (11-beta) dehydrogenase 1

2.80

0.0325

2.20

0.0874

AL031228

HSD17B8

Hydroxysteroid (17-beta) dehydrogenase 8

2.80

0.0258

2.20

0.0620

Other peroxisomal proteins

AU147084

CAT

Catalase

8.63

0.0028

5.78

0.0069

Others

NM_000072

CD36

CD36 molecule (thrombospondin receptor)

48.18

0.0001

16.11

0.0008

  1. a Mean fold changes were calculated using a division of raw expression values between experimental sample and uninfected control.
  2. b All samples were analyzed separately. Changes in gene expression with a cutoff of 2.0-fold increased or decreased expression was used and, the p-value was calculated by Student's t-test. Data are displayed only where the, p ≤ 0.05. This p-value was used as a measure of the magnitude of the difference between groups and to determine significance of the modulation. The modulated genes in the pathway are listed in alphabetic order.
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Virology Journal

ISSN: 1743-422X