Gene expression in primate liver during viral hemorrhagic fever

Djavani, Mahmoud; Crasta, Oswald R; Zhang, Yan; Zapata, Juan Carlos; Sobral, Bruno; Lechner, Melissa G; Bryant, Joseph; Davis, Harry; Salvato, Maria S

doi:10.1186/1743-422X-6-20

Table 3 Expression of genes involved with TCA cycle and glucose metabolism in LCMV-WE infected macaque liver

From: Gene expression in primate liver during viral hemorrhagic fever

			Pre-viremic		Viremic
GenBank Accession no.	Symbol	Gene description	Fold change^a	p ^b	Fold change^a	p ^b
*Citric acid cycle*
NM_001096	ACLY	ATP citrate lyase	2.14	0.0809	3.58	0.0040
AI363836	FH	Fumarate hydratase	5.54	0.0045	3.05	0.0356
AI826060	IDH3A	Isocitrate dehydrogenase 3 (NAD+) alpha	1.51	0.4150	2.29	0.0440
AF023266	IDH3B	Isocitrate dehydrogenase 3 (NAD+) beta	2.41	0.0219	2.19	0.0290
NM_004135	IDH3G	Isocitrate dehydrogenase 3 (NAD+) gamma	2.14	0.0262	2.29	0.0122
NM_005917	MDH1	Malate dehydrogenase 1, NAD (soluble)	9.51	0.0056	9.25	0.0039
BC001917	MDH2	Malate dehydrogenase 2, NAD (mitochondrial)	2.77	0.0739	3.48	0.0221
NM_004168	SDHA	Succinate dehydrogenase complex, A, flavoprotein	4.17	0.0108	4.03	0.0087
NM_003000	SDHB	Succinate dehydrogenase complex, B, iron sulfur	5.98	0.0120	6.68	0.0056
AF080579	SDHC	Succinate dehydrogenase complex, C, membrane protein	14.12	0.0003	11.63	0.0003
AL050226	SUCLG2	Succinate-CoA ligase, GDP-forming, beta	4.23	0.0108	2.83	0.0442
*Glycolysis*
NM_000034	ALDOA	Aldolase A, fructose-bisphosphate	2.03	0.0136	3.05	0.0004
AK026411	ALDOB	Aldolase B, fructose-bisphosphate	14.83	0.0002	6.02	0.0027
AK026525	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	6.59	0.0034	4.89	0.0066
M69051	GCK	Glucokinase (hexokinase 4)	3.92	0.0010	1.01	0.9980
S81916	PGK1	Phosphoglycerate kinase 1	23.59	0.0009	23.43	0.0005
NM_002633	PGM1	Phosphoglucomutase 1	6.28	0.0038	5.03	0.0058
*Glycogen metabolism*
S70004	GYS2	Glycogen synthase 2, liver	9.65	0.0004	5.54	0.0020
NM_002863	PYGL	Phosphorylase glycogen, liver	4.96	0.0120	3.14	0.0485
NM_002633	PGM1	Phosphoglucomutase 1	6.28	0.0038	5.03	0.0058
*Gluconeogenesis*
D26054	FBP1	Fructose-1,6-bisphosphatase 1	4.08	0.0061	1.59	0.1559
BC020700	G6PC	Glucose-6-phosphatase, catalytic	12.13	0.0034	5.17	0.0265
*Others*
NM_000284	PDHA1	Pyruvate dehydrogenase (lipoamide) alpha 1	3.48	0.0769	4.53	0.0249

^a Mean fold changes were calculated using a division of raw expression values between experimental sample and uninfected control.
^b All samples were analyzed separately. Changes in gene expression with a cutoff of 2.0-fold increased or decreased expression was used and, the p-value was calculated by Student's t-test. Data are displayed only where the, p ≤ 0.05. This p-value was used as a measure of the magnitude of the difference between groups and to determine significance of the modulation. The modulated genes in the pathway are listed in alphabetic order.

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