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Table 3 Expression of genes involved with TCA cycle and glucose metabolism in LCMV-WE infected macaque liver

From: Gene expression in primate liver during viral hemorrhagic fever

    Pre-viremic Viremic
GenBank Accession no. Symbol Gene description Fold changea p b Fold changea p b
Citric acid cycle
NM_001096 ACLY ATP citrate lyase 2.14 0.0809 3.58 0.0040
AI363836 FH Fumarate hydratase 5.54 0.0045 3.05 0.0356
AI826060 IDH3A Isocitrate dehydrogenase 3 (NAD+) alpha 1.51 0.4150 2.29 0.0440
AF023266 IDH3B Isocitrate dehydrogenase 3 (NAD+) beta 2.41 0.0219 2.19 0.0290
NM_004135 IDH3G Isocitrate dehydrogenase 3 (NAD+) gamma 2.14 0.0262 2.29 0.0122
NM_005917 MDH1 Malate dehydrogenase 1, NAD (soluble) 9.51 0.0056 9.25 0.0039
BC001917 MDH2 Malate dehydrogenase 2, NAD (mitochondrial) 2.77 0.0739 3.48 0.0221
NM_004168 SDHA Succinate dehydrogenase complex, A, flavoprotein 4.17 0.0108 4.03 0.0087
NM_003000 SDHB Succinate dehydrogenase complex, B, iron sulfur 5.98 0.0120 6.68 0.0056
AF080579 SDHC Succinate dehydrogenase complex, C, membrane protein 14.12 0.0003 11.63 0.0003
AL050226 SUCLG2 Succinate-CoA ligase, GDP-forming, beta 4.23 0.0108 2.83 0.0442
Glycolysis
NM_000034 ALDOA Aldolase A, fructose-bisphosphate 2.03 0.0136 3.05 0.0004
AK026411 ALDOB Aldolase B, fructose-bisphosphate 14.83 0.0002 6.02 0.0027
AK026525 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 6.59 0.0034 4.89 0.0066
M69051 GCK Glucokinase (hexokinase 4) 3.92 0.0010 1.01 0.9980
S81916 PGK1 Phosphoglycerate kinase 1 23.59 0.0009 23.43 0.0005
NM_002633 PGM1 Phosphoglucomutase 1 6.28 0.0038 5.03 0.0058
Glycogen metabolism
S70004 GYS2 Glycogen synthase 2, liver 9.65 0.0004 5.54 0.0020
NM_002863 PYGL Phosphorylase glycogen, liver 4.96 0.0120 3.14 0.0485
NM_002633 PGM1 Phosphoglucomutase 1 6.28 0.0038 5.03 0.0058
Gluconeogenesis
D26054 FBP1 Fructose-1,6-bisphosphatase 1 4.08 0.0061 1.59 0.1559
BC020700 G6PC Glucose-6-phosphatase, catalytic 12.13 0.0034 5.17 0.0265
Others
NM_000284 PDHA1 Pyruvate dehydrogenase (lipoamide) alpha 1 3.48 0.0769 4.53 0.0249
  1. a Mean fold changes were calculated using a division of raw expression values between experimental sample and uninfected control.
  2. b All samples were analyzed separately. Changes in gene expression with a cutoff of 2.0-fold increased or decreased expression was used and, the p-value was calculated by Student's t-test. Data are displayed only where the, p ≤ 0.05. This p-value was used as a measure of the magnitude of the difference between groups and to determine significance of the modulation. The modulated genes in the pathway are listed in alphabetic order.