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Table 3 Nucleotide positions (aligned) of fixed mutations in avian influenza A virus (segment 8 genotype 1E) genomes

From: Evidence for a novel gene associated with human influenza A viruses

Position

NS1 protein

NEG8 reading frame

NS2 protein

169

S>N

no change

 

239

no change

no change

 

311

no change

no change

 

341

no change

I>M

 

350

no change

no change

 

379

R>K

no change

 

404

no change

no change

 

407

no change

I>M

 

447

no change

S>N

 

538

M>V

I>T

 

618

no change

R>I

L>I

625

K>R

F>S

N>D

661

P > L

G>S

L>F

677

K>N

Y>*

S>I

729

 

I>T

no change

780

 

Q>R

no change

  1. Of 16 fixed single-nucleotide mutations in the avian influenza A viruses in the region of genome segment 8 spanning the region equivalent to the NEG8 ORF, 5 had no effect on NS1, NS2 or NEG8 reading frames, 8/14 had no effect on NS1, 2/6 had no effect on NS2. 9/16 mutations resulted in a change in the predicted amino acid sequence of the NEG8 protein.