Table 1 Selected siRNA Targets
From: Inhibition of Monkeypox virus replication by RNA interference
MPV ORF | VACV ORF | Gene size(bp) | Region | Known or predicted function |
|---|---|---|---|---|
A5L | A4L | 846 | 113340-114185 | 39 kDa immunodominant virion core protein needed for the progression of IV to infectious IMV |
A6R | A5R | 486 | 114223-114708 | Precursor of RNA polymerase 22 kDa |
C14L | F8L | 195 | 35828-36022 | No information available |
C2L | K2L | 1128 | 26384-27511 | Serine protease inhibitor-like, SPI-3; inhibition of the ability of infected cells to fuse |
C3L | K3L | 132 | 27672-27803 | Interferon resistance; host defense modulator |
E8L | D8L | 915 | 103116-104030 | IMV cell attachment, putative; blockage causes plaque reduction |
F8L | E9L | 3021 | 53691-56711 | DNA polymerase, catalytic subunit |
H1L | H1L | 516 | 87256-87771 | Tyrosine/serine protein phosphatase; blocks IFN-γ |
H3L | H3L | 975 | 88358-89332 | IMV cell attachment; heparin binding surface protein involved in IMV maturation |
I3L | I3L | 810 | 61085-61894 | Virosomal ssDNA-binding phosphoprotein; interacts with R2 subunit of ribonucleotide reductase |
L5L | J5L | 402 | 82891-83292 | Essential for virus multiplication |
P1L | N1L | 354 | 22056-22409 | Virokine; host defense modulator |