Skip to main content

Table 3 Final proportions of cells (% of the total) after 13 years

From: Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success

 

Uninfected cells

Infected cells

 

Untransduced

Transduced

Untransduced

Transduced

Scenario

   

m = 0

m = 1

m = 2

1

1.3

63.5

35.1

0.1

0.005

0.0003

2

0.7

61.8

35.2

2.4

0.08

0

3

0.1

25.7

38.2

35.6

0.5

0

4

1.2

63.5

35.0

0.3

0.01

0

5

0.9

62.6

35.1

1.4

0.04

0.0003

6

0.6

61.5

35.1

2.7

0.08

0

7

0.4

59.8

35.4

4.3

0.1

0.001

  1. The percentage of untransduced and transduced cells that are uninfected and infected after 5000 days (13 years) of modeling. The resistance profiles for the transduced cells that are infected are also shown, divided into the percentage of total cells infected with wildtype virus (m = 0) and virus containing mutations that confer complete resistance to either 1 (m = 1) or 2 shRNAs (m = 2). n.b. we observed no strains that developed resistance to more than 2 shRNAs.