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Figure 1 | Virology Journal

Figure 1

From: The interaction of hepatitis A virus (HAV) with soluble forms of its cellular receptor 1 (HAVCR1) share the physiological requirements of infectivity in cell culture

Figure 1

Schematic representation of Fc fusion proteins. D1muc-Fc is a soluble form of HAVCR1 containing the IgV and two-thirds of the mucin-like domain of HAVCR1 fused to the hinge and Fc regions of human IgG1. A FLAG tag consisting of 8 amino acid residues was introduced between the HAVCR1 and hinge portions. PVR-Fc, a soluble receptor form containing the whole ectodomain of the poliovirus receptor fused to the same hinge and Fc fragment of human IgG1 was used as a negative control fusion protein. Construction and purification of D1muc-Fc and PVR-Fc was done as described [17].

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Virology Journal

ISSN: 1743-422X