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Table 1 Particle size and viral strain specific LD50 determination, by speciess

From: Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs

Species

EEE strain

Particle (μm)

LD50 (PFU)

95% fiducial limits

MTDa (days)

    

lower

upper

 

guinea pig

Hartley

ArgM

1

5.2E+03

2.9E+03

2.4E+04

6.0

  

> 3b

n/cc

-d

-

5.0

 

NJ1959

1

1.1E+04

3.5E+03

8.9E+04

5.0

  

> 3

3.0E+04

9.1E+03

7.6E+05

5.8

mouse

BALB/c

ArgM

1

4.6E+02

1.9E+02

1.7E+03

6.0

  

> 3

n/cc

-

-

4.7

 

NJ1959

1

6.2E+02

-

-

5.8

  

> 3

2.9E+03

1.1E+03

1.1E+04

5.8

  1. a Mean time to death
  2. b Considered 'larger' particle distribution due to bimodal size distribution
  3. c LD50 could not be estimated because no dose group had more than 50% mortality
  4. d The confidence limits were not determined due to lack of mortality in selected groups