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Figure 4 | Virology Journal

Figure 4

From: Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions

Figure 4

UL56 localizes to cytoplasmic vesicular structures in HSV-2 infected cells. Cells infected with wild-type viruses were fixed at 6 h postinfection (A) or 9 h postinfection (B), and immunostained as described in Fig. 3. UL56 (shown in green) accumulated in the perinuclear region with vesicular distribution in the cytoplasm. UL56 predominantly colocalized with marker proteins for TGN (TGN46, γ-adaptin and δ-adaptin), and partially with marker proteins for Golgi complex proteins (Golgi58K and GM130) and early endosomes (EEA1) (shown in red). Little or no overlap was detected between UL56 and either rab7 or CD63. Scale bars, 10 μm.

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Virology Journal

ISSN: 1743-422X