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Table 1 Evolutionary distances within the four patients, controls and between patients and controls on env, gag and pol genes a

From: A HIV-1 heterosexual transmission chain in Guangzhou, China: a molecular epidemiological study

 

env

gag

pol

 

Distance

Sample size

p-value b

Distance

Sample size

p-value b

Distance

Sample size

p-value b

Patients c

5.23 ± 0.85

n = 4

1.19 × 10-11

2.39 ± 0.60

n = 4

6.37 × 10-13

1.54 ± 0.22

n = 4

5.12 × 10-14

Controls

11.02 ± 0.92

n = 23

-

6.27 ± 0.66

n = 32

-

2.95 ± 0.18

n = 25

-

Between-group

14.21 ± 1.48

-

-

8.23 ± 1.15

-

-

4.12 ± 0.37

-

-

  1. a Within-group mean nucleotide distances measured as substitutions per 100 sites with estimated 95% standard of error between selected HIV-1 gene sequences. Between-group mean nucleotide distances measured as substitutions per 100 sites with estimated 95% standard error comparing selected HIV-1 gene sequences from the four patients to equivalent sequences from local controls. The control group is randomly selected non-clustered CRF01_AE sequences.
  2. b Unpaired t-test p-value calculated with respect to controls.
  3. c Evolutionary distances of all genes are significantly different from the corresponding gene among control sequences (p = 1.19 × 10-11, p = 6.37 × 10-13 and p = 5.12 × 10-14 respectively).
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Virology Journal

ISSN: 1743-422X