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Table 2 Comparison of distinct amino acid variations in the indicated functional domains of F protein between groups or subgroups of unique human metapneumovirus strains.

From: Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years

Functional domain AA residues in domain No. of AA AA Position A (n = 36) B (n = 49) A1 (n = 13) A2 (n = 23) B1 (n = 11) B2 (n = 38)
Signal peptide 1-22 2 6 V M/V V V M/V M/V
    9 F I     
F2 subunit 23-102 2 61 A/S T/(S*) A A/S T T/(S*)
    82    R K K K
Fusion peptide 103-125 1 122 V I     
Heptad repeat A 131-172 4 135 T N     
    139 N G     
    143    K K/T Q/(K*) K/T
    167 D E     
F1 subunit 173-453 10 175 R S     
    185 A/D A A D A A
    233 N Y     
    286 V I     
    296 K/R N/D K K/R N/(D*) D
    312 Q K     
    348 K R     
    404 N/S P N N/S P P
    449 V/I I V V/I I I
    450 K R/K     
Heptad repeat B 454-486 3 466 S/N S S N/S S S
    479 R K/(R*) R R K/(R*) K
    482 S/(N*) N/(S*) S S/(N*) N/(S*) N
Transmembrane 490-514 6 498 I I/V I I V I
    503 S L     
    504 T/S T/A T S T T/A
    507 L S     
    510 V/I I V V/I I I
    511 F I     
Cytoplasmic tail 515-539 4 518 K/(R*) R/(K*) K K/(R*) R/(K*) R
    528 S N     
    533 N G     
    539    N/(S*) S/N S S
  1. Amino acids (AA) in bold type did not vary within the group or subgroup.
  2. *Amino acids found in only one isolate within the group or subgroup.