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Table 2 Comparison of distinct amino acid variations in the indicated functional domains of F protein between groups or subgroups of unique human metapneumovirus strains.

From: Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years

Functional domain

AA residues in domain

No. of AA

AA Position

A

(n = 36)

B

(n = 49)

A1

(n = 13)

A2

(n = 23)

B1

(n = 11)

B2

(n = 38)

Signal peptide

1-22

2

6

V

M/V

V

V

M/V

M/V

   

9

F

I

    

F2 subunit

23-102

2

61

A/S

T/(S*)

A

A/S

T

T/(S*)

   

82

  

R

K

K

K

Fusion peptide

103-125

1

122

V

I

    

Heptad repeat A

131-172

4

135

T

N

    
   

139

N

G

    
   

143

  

K

K/T

Q/(K*)

K/T

   

167

D

E

    

F1 subunit

173-453

10

175

R

S

    
   

185

A/D

A

A

D

A

A

   

233

N

Y

    
   

286

V

I

    
   

296

K/R

N/D

K

K/R

N/(D*)

D

   

312

Q

K

    
   

348

K

R

    
   

404

N/S

P

N

N/S

P

P

   

449

V/I

I

V

V/I

I

I

   

450

K

R/K

    

Heptad repeat B

454-486

3

466

S/N

S

S

N/S

S

S

   

479

R

K/(R*)

R

R

K/(R*)

K

   

482

S/(N*)

N/(S*)

S

S/(N*)

N/(S*)

N

Transmembrane

490-514

6

498

I

I/V

I

I

V

I

   

503

S

L

    
   

504

T/S

T/A

T

S

T

T/A

   

507

L

S

    
   

510

V/I

I

V

V/I

I

I

   

511

F

I

    

Cytoplasmic tail

515-539

4

518

K/(R*)

R/(K*)

K

K/(R*)

R/(K*)

R

   

528

S

N

    
   

533

N

G

    
   

539

  

N/(S*)

S/N

S

S

  1. Amino acids (AA) in bold type did not vary within the group or subgroup.
  2. *Amino acids found in only one isolate within the group or subgroup.
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Virology Journal

ISSN: 1743-422X