Skip to main content

Advertisement

Table 2 Functional immunological properties from MARV epitopes

From: Discovery of common marburgvirus protective epitopes in a BALB/c mouse model

Name and Location 9-mer Sequence % Lysis on CTL Assaya Adoptive Transfer % Survivalb
VP44 KNPNNGPLL 6 40
NP144 NSGIDLGDL 16 80
NP150 NTSPVAKYL 15 20
NP157 HYSPLILAL Not done 10
GP2 ILIQGTKNL 17 50
GP3 QGTKNLPIL 20 20
GP21 LLLDPPTNI Not done 0
GP84 TPSSTAQHL Not done 0
GP132 LLLSIAVLI 40 100
GP133 LSIAVLIAL Not done 20
GP134 IALSCICRI 6 40
PBS N/A 2 10
  1. a% of cells lysed when compared to Triton-X-treated targets
  2. bSurvival after transfer of epitope-specific splenocytes and challenge with lethal PFU (~1000) of MARV, n = 10 BALB/c mice/group