Discovery of common marburgvirus protective epitopes in a BALB/c mouse model

Table 1 Selection of MARV epitopes

Peptide Pool^a	+ Peptide from Pool^b	15-mer Sequence	% CD8 IFNγ^c	9-mer Peptide Motif Results^d	% CD8 IFNγ ^e
GP1-13	GP2	FLISLILIQGTKNLP	2.85	ILIQGTKNL	2.83
GP1-14	GP3	ILIQGTKNLPILEIA	5.09	QGTKNLPIL	3.46
GP2-17	GP19	TCYNISVTDPSGKSL	2.34	VTDPSGKSL	1.68
GP2-19	GP21	SGKSLLLDPPTNIRD	2.6	LLLDPPTNI	1.72
GP7-17	GP84	SPPPTPSSTAQHLVY	3.11	TPSSTAQHL	2.93
GP11-13	GP132	GILLLLSIAVLIALS	8.36	LLLSIAVLI	8.94
GP11-14	GP133	LSIAVLIALSCICRI	2.96	LSIAVLIAL	1.18
GP11-15	GP134	LIALSCICRIFTKYI	2.73	IALSCICRI	4.12
NP1-20	NP144	AINSGIDLGDLLEGG	2.88	NSGIDLGDL	4.13
NP2-13	NP150	KFNTSPVAKYLRDAG	2.53	NTSPVAKYL	4.71
NP2-20	NP157	EPHYSPLILALKTLE	3.48	HYSPLILAL	2.79
VP6-12	VP44	QHKNPNNGPLLAISG	3.17	KNPNNGPLL	2.38

*Tested in adoptive transfer studies
^aPools of peptides were each number represents a new 15-mer peptide
^bSelected 15-mer peptides capable of restimulating splenocytes of MARV-infected mice
^cMean IFNγ levels from two experiments minus mean background
^d9 mers derived from HLA binding predictions

ISSN: 1743-422X