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Figure 3 | Virology Journal

Figure 3

From: Discovery of common marburgvirus protective epitopes in a BALB/c mouse model

Figure 3

A, Survival rates for mice receiving NP and VP40 9-mer-stimulated splenocytes prior to lethal MARV challenge. NP144-stimulated splenocytes offered significant protection (8/10; p < 0.05) against lethal MARV challenge when compared to nonstimulated splenocytes when transferred into naïve mice (1/10). NP150-, NP157-, and VP44-stimulated MARV-specific splenocytes did not significantly protect naïve mice from lethal MARV challenge. B, Splenocytes from previously MARV-infected mice were stimulated with 9-mer peptides and transferred into naïve animals prior to lethal MARV infection. Survival rates were monitored up to 12 days postinfection. Naïve BALB/c mice receiving GP132-stimulated splenocytes were fully protected from lethal MARV (10/10; p < 0.05). GP2-, GP3-, GP21-, GP84-, GP133-, and GP134-stimulated and transferred splenocytes did not individually protect naïve mice from lethal MARV challenge when compared to mice receiving nonstimulated splenocytes from mice previously infected with nonlethal MARV (1/10).

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