Table 1 The reduction rate of HCV-Core protein expression and HCV-RNA level in Huh-7 cells supporting HCV replication inhibited by siRNA.
From: Consensus siRNA for inhibition of HCV genotype-4 replication
Days | **RNA titer (untransfected) IU/ml | **RNA titer (Z3 used) IU/ml | **RNA titer (Z5 used) IU/ml | * Core protein reduction rate (Z5 used) | * Core protein reduction rate (Z3 used) |
|---|---|---|---|---|---|
1 | 4 × 106 | 4 × 106 | 3.6 × 105 | 10% | 0% |
2 | 3.9 × 106 | 3 × 106 | 2.4 × 105 | 60% | 75% |
3 | 4.1 × 106 | > 1000 | > 1000 | 90% | 100% |
4 | 4.2 × 106 | > 1000 | > 1000 | 100% | 100% |
5 | 4.5 × 106 | 2.2 × 106 | > 1000 | 100% | 50% |
6 | 3.8 × 106 | 2.89 × 106 | > 1000 | 100% | 30% |
7 | 3.7 × 106 | 3.1 × 106 | 1.6 × 106 | 40% | 30% |
8 | 4.4 × 106 | 4 × 106 | 4.2 × 106 | 0% | 0% |