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Table 1 Inhibition by PVP-I of sialidase activity, hemagglutination and infectivity activity of influenza A viruses

From: Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities

Virus subtype Virus strain Sialidase inhibition activity
IC50a (μg/ml)
Hemagglutination inhibition activityb (mg/ml) Infection inhibitory activity (%)c
H1N1 A/Bel/42 11 ± 2 1.56 84 ± 1
  A/Texas/36/91 72 ± 4 0.78 68 ± 3
  A/USSR/92/77 47 ± 3 0.78 68 ± 2
  A/PR/8/34 9.5 ± 0.5 0.20 62 ± 2
  A/WS/33 12.5 ± 0.5 0.78 60 ± 4
  A/WSN/33 45 ± 1 0.39 97 ± 1
  A/DK/HK/36/4 21 ± 5 12.50 40 ± 4
H3N2 A/Aichi/2/68 96 ± 2 3.13 82 ± 5
  A/Memphis/1/71 61 ± 4 1.56 66 ± 3
H9N2 A/DK/HK/92/76 212 ± 9 12.50 34 ± 8
H5N3 A/DK/HK/313/78 78 ± 4 12.50 23 ± 1
  A/DK/HK/23/76 124 ± 7 3.13 57 ± 4
  A/DK/HK/677/1 55 ± 1 3.13 50 ± 3
  1. aIC50values are concentrations inhibiting viral sialidase activity by 50%. Standard error means were calculated from means of two independent experiments, each conducted in duplicate.
  2. bMinimum concentration that inhibits hemagglutination.
  3. cPercent viral inhibition (with 1.56 mg/ml of PVP-I) was calculated by comparison with the control without an inhibitor. Each experiment was performed in triplicate.