A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: Potential impact on CTL epitopes

Table 16 The extent of amino acid polymorphisms in experimentally defined CTL epitopes

Location of the epitope in Vpr	Amino acid sequence	Total number of variant amino acids in the CTL epitope	Reference
1 – 18	MEQAPENQGLQREPYNEW	87	[86]
9 – 26	GPQREPYNEWTLELLEEL	87	[87]
12 – 20	REPHNEWTL	53	[28, 88, 89]
19 – 28	TLEILEELKN	51	[86]
25 – 40	ELKNEAVRHFPRIWLH	87	[90]
29 – 37	EAVRHFPRI	52	[91–94]
30 – 38	AVRHFPRIW	52	[28, 88, 95]
31 – 50	VRHFPRWLHSLGQYIYETY	107	[96]
31 – 39	VRHFPRIWL	48	[97]
34 – 42	FPRIWLHGL	58	[28, 87, 89, 97–103]
41 – 49	SLGQHIYET	49	[99]
41 – 57	GLGQYIYETYGDTWTGV	82	[87]
46 – 54	IYETYGDTW	36	[104]
48 – 57	ETYGDTWTGV	50	[87, 97]
52 – 62	DTWAGVEAIIR	66	[97]
53 – 63	TWAVEAIIRI	69	[92]
55 – 70	AGVEAIIRILQQLLFI	86	[28]
59 – 67	AIIRILQQL	49	[10, 28, 89, 96, 98, 105, 106]
62 – 70	RILQQLLFI	38	[89, 98, 106]

ISSN: 1743-422X