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Table 16 The extent of amino acid polymorphisms in experimentally defined CTL epitopes

From: A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: Potential impact on CTL epitopes

Location of the epitope in Vpr Amino acid sequence Total number of variant amino acids in the CTL epitope Reference
1 – 18 MEQAPENQGLQREPYNEW 87 [86]
9 – 26 GPQREPYNEWTLELLEEL 87 [87]
12 – 20 REPHNEWTL 53 [28, 88, 89]
19 – 28 TLEILEELKN 51 [86]
25 – 40 ELKNEAVRHFPRIWLH 87 [90]
29 – 37 EAVRHFPRI 52 [9194]
30 – 38 AVRHFPRIW 52 [28, 88, 95]
31 – 50 VRHFPRWLHSLGQYIYETY 107 [96]
31 – 39 VRHFPRIWL 48 [97]
34 – 42 FPRIWLHGL 58 [28, 87, 89, 97103]
41 – 49 SLGQHIYET 49 [99]
41 – 57 GLGQYIYETYGDTWTGV 82 [87]
46 – 54 IYETYGDTW 36 [104]
48 – 57 ETYGDTWTGV 50 [87, 97]
52 – 62 DTWAGVEAIIR 66 [97]
53 – 63 TWAVEAIIRI 69 [92]
55 – 70 AGVEAIIRILQQLLFI 86 [28]
59 – 67 AIIRILQQL 49 [10, 28, 89, 96, 98, 105, 106]
62 – 70 RILQQLLFI 38 [89, 98, 106]