From: Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach
A. | Â | Â |
---|---|---|
Insert | HVR2 | HVR5 |
33RGD Motif + 12 aa Linker | + | + |
43RGD Motif + 12 aa Linker | - | + |
53RGD Motif + 12 aa Linker | - | + |
63RGD Motif + 12 aa Linker | - | - |
73RGD Motif + 12 aa Linker | - | - |
83RGD Motif + 12 aa Linker | - | - |
(+) = viable viruses (-) = not viable viruses. | ||
B. | Â | Â |
33RGD motif- | AAAMQPVEDMNDHAI RGD TFATRAEEKRAEAEA | |
43RGD motif- | NSNAAAAAMQPVEDMNDHAI RGD TFATRAEEKRAEAEAAAEAA | |
53RGD motif- | SGAEENSNAAAAAMQPVEDMNDHAI RGD TFATRAEEKRAEAEAAAEAAAPAAQ | |
63RGD motif- | SNSSGSGAEENSNAAAAAMQPVEDMNDHAI RGD TFATRAEEKRAEAEAAAEAAAPAAQPEVEK | |
73RGD motif- | GGAGGSNSSGSGAEENSNAAAAAMQPVEDMNDHAI RGD TFATRAEEKRAEAEAAAEAAAPAAQPEVEKPQKKP | |
83RGD motif- | TEQGGGGAGGSNSSGSGAEENSNAAAAAMQPVEDMNDHAI RGD TFATRAEEKRAEAEAAAEAAAPAAQPEVEKPQKKPVIKPL |