Skip to main content

Table 1 In vitro virus neutralization exhibited by 7C8 Fab and 3C4 Fab fragments given as the concentration of Fab needed for IC80 neutralization.

From: HIV-2 neutralization by intact V3-specific Fab fragments

  Virus   Fab Fragment
Isolate Subtype Coreceptor
usage+
TCID50   7C8
(μg/ml)
3C4
(μg/ml)
HIV-2SBL6669 A CCR3, CXCR4 42   0.63 0.31
    15   0.63 < 0.16
HIV-2K135 unknown CCR5* 435^   - 6.25
    18   0.63 0.31
HIV-21682 A CCR1, CCR3, CCR5 28   - 6.25
HIV-21653 B CCR5 18   - 6.25
HIV-22298 A CCR5 18   - 12.50
SIVsm n/a CCR5, BOB 44   - 3.13
  1. + Co-receptor usage according to Mörner et al. [11] and Vödrös et al. [30].
  2. * Determined by Jose M. Marcelino (personal communication).
  3. n/a Not applicable.
  4. ^ Very high virus inoculum dose.
  5. - No neutralization observed up to 100 μg/ml.