Correlating novel variable and conserved motifs in the Hemagglutinin protein with significant biological functions

Table 6 Co-mutating pairs and their position with respect to MEME motifs.

Co-mutating pairs	MEME Motif	MEME Motif	Co-mutating pairs	MEME Motif	MEME Motif
	(position 1)	(position 2)		(position 1)	(position 2)
I-78-D-18	9	2	Q-205-I-78	2	9
T-99-I-78	1	9	Q-205-T-99	2	1
G-140-D-18	7	2	Q-205-P-159	2	7
G-140-I-78	7	9	Q-205-T-171	2	11
G-151-G-140	7	7	Q-205-T-176	2	11
N-153-D-18	7	2	S-209-T-99	13	1
N-153-I-78	7	9	S-209-Q-205	13	2
P-159-D-18	7	2	V-212-N-153	13	7
P-159-I-78	7	9	V-212-Q-205	13	2
P-159-T-99	7	1	V-260-D-18	6	2
P-159-G-140	7	7	V-260-T-99	6	1
P-159-N-153	7	7	V-260-G-140	6	7
G-160-D-18	7	2	V-260-N-153	6	7
G-160-I-78	7	9	V-260-P-159	6	7
N-161-D-18	7	2	V-260-G-160	6	7
N-161-I-78	7	9	V-260-N-161	6	7
N-161-G-140	7	7	V-260-Q-205	6	2
N-161-N-153	7	7	N-264-D-18	6	2
N-161-P-159	7	7	N-264-T-99	6	1
T-171-A-14	11	2	N-264-N-153	6	7
T-171-T-99	11	1	N-264-P-159	6	7
T-171-P-159	11	7	N-264-N-161	6	7
K-172-N-153	11	7	N-264-Q-205	6	2
K-172-P-159	11	7	I-294-D-18	-	2
K-172-N-161	11	7	I-294-T-99	-	1
G-174-D-18	11	2	I-294-N-153	-	7
G-174-G-140	11	7	I-294-P-159	-	7
G-174-N-153	11	7	I-294-N-161	-	7
G-174-P-159	11	7	I-363-N-153	1	7
G-174-G-160	11	7	I-363-N-161	1	7
G-174-N-161	11	7	I-363-G-174	1	11
T-176-D-18	11	2	I-363-V-212	1	13
T-176-T-99	11	1	I-363-I-294	1	-
T-176-G-140	11	7	V-400-D-18	9	2
T-176-N-153	11	7	V-400-G-140	9	7
T-176-P-159	11	7	V-400-N-153	9	7
T-176-G-160	11	7	V-400-P-159	9	7
T-176-N-161	11	7	V-400-G-160	9	7
			V-400-N-161	9	7

77 co-mutating pairs implicated in MEME blocks 1, 2, 3, and 7 were determined using CRASP (see materials and methods) and aligned with MEME motifs.

ISSN: 1743-422X