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Table 3 Positions of potential post-translational modification sites

From: Correlating novel variable and conserved motifs in the Hemagglutinin protein with significant biological functions

Motif ID

Expression

Start

position of

the motif

End

position of

the motif

Years observed

CK2_PHOSPHO_SITE Casein kinase II phosphorylation site.

[ST]-x(2)-[DE].

44

47

1968,1969,1971,1972

  

81

84

 
  

142

145

1972

  

203

206

 
  

416

419

 
  

432

435

 
  

456

459

 

PKC_PHOSPHO_SITE Protein kinase C phosphorylation site

[ST]-x-[RK]

64

66

All years except 1982

  

123

125

 
  

152

154

 
  

154

156

 
  

159

161

 
  

173

175

1972

  

190

192

1975

  

203

205

1975, 1980, 1982, 1983, 1984, 1985, 1987, 1988, 1989, 1992

  

215

217

 
  

221

223

 
  

222

224

 
  

243

245

 
  

278

280

 
  

329

331

 
  

467

469

 
  

496

498

 

cAMP_PHOSPHO_SITE cAMP- and cGMP-dependent protein kinase phosphorylation site.

[RK](2)-x-[ST]

156

159

1975, 1980, 1982, 1983, 1984, 1985, 1987, 1988, 1989, 1992, 1999

ASN_GLYCOSYLATION N-glycosylation site

N-{P}-[ST]-{P}

24

27

All years except 1971, 1972

  

38

41

 
  

54

57

 
  

79

82

1975, 1980, 1982, 1983, 1984, 1985, 1987, 1988, 1989, 1992, 1999

  

97

100

1968, 1969, 1971, 1972, 1973

  

138

141

1999

  

142

145

1974, 1980, 1982, 1983, 1984, 1985, 1987, 1988, 1989, 1992, 1999

  

149

152

1999

  

181

184

 
  

262

265

1980, 1982, 1983,

1984, 1985, 1987,

1988, 1989, 1992,

1999

  

301

304

 
  

499

502

 

MYRISTYL

N-myristylation site

G-{EDRKHPFYW}-

x(2)-[STAGCN]-{P}.

21

26

 
  

77

82

1968,1969,1971,1972,

1973, 1974, 1975

  

145

150

All years except 1972

  

150

155

All years except 1989,

1992

  

151

156

All years except 1989,

1992, and 1999

  

158

163

1975, 1980, 1982,

1983, 1984, 1985,

1987, 1988, 1989,

1992,

  

291

296

1974, 1975, 1980,

1982, 1983, 1984,

1985, 1987, 1988,

1989, 1992,

  

302

307

 
  

346

351

 
  

349

354

 
  

361

366

 
  

376

381

 
  

495

500

1973, 1974, 1975,

1980, 1982, 1983,

1984, 1985, 1987,

1988, 1989, 1992,

  

558

563

All years except 1989,

  1. Prosite motifs detected for the H3N2 sequences using PPSearch this includes 24 phosphorylation, 12 glycosylation and 14 myristylation sites. Potential phosphorylation sites include casein kinase II phosphorylation site, protein kinase C phosphorylation site and cAMP- and cGMP-dependent protein kinase phosphorylation site, ASN glycosylation motifs and N-myristylation sites. The start and end positions of each motif are shown, as well as the regular expression of the motif. Unless otherwise indicated, sites have been observed in all 17 consensus sequences.