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Table 2 Amino acid substitutions in the different isolates from 1969–1999 used to extrapolate the genetic distance in the different MEME blocks

From: Correlating novel variable and conserved motifs in the Hemagglutinin protein with significant biological functions

YEARS Number of
amino acid
substitutions
% CHANGE
BETWEEN YEARS
MEME
Block
Genetic
Distance
1968–1969 5 0.883392 1 0.08943
1969–1971 12 1.943463 2 0.3678
1971–1972 11 1.943463 3 0.228
1972–1973 22 3.886926 4 0.16
1973–1974 5 0.883392 5 0.142
1974–1975 15 2.650177 6 0.293
1975–1980 29 4.946997 7 0.8292
1980–1982 6 1.060071 8 0.048
1982–1983 13 2.296820 9 0.288
1983–1984 2 0.353357 10 0.212
1984–1985 1 0.176678 11 2
1985–1987 7 1.236749 12 0.167
1987–1988 3 0.530035 13 1.833
1988–1989 8 1.423488   
1989–1992 10 2.473498   
1992–1999 23 4.240283   
  1. Using ClustalW alignment the number of observed substitutions for each of the consensus sequence and the equivalent years are tabulated using Infoalign. The highest aminoacid substitution (29 aa substitutions over the entire sequence) was in Years 1980. The genetic distance in each MEME block is calculated showing that MEME blocks 1 and 8 are conserved (bold), MEME blocks 7, 11 and 13 are highly variable and the other MEME blocks show intermediate variability.