Figure 5
Average entropy of specific post-translational modification sites in each of the MEME blocks is demonstrated using boxplot. (A) Average entropy of potential CKII phosphorylation sites in the MEME blocks. Blocks 1, 5 and 9 have zero entropy at all CKII sites. The majority of MEME blocks 2 and 7 CKII sites have nonzero entropy. One of the MEME block 2 CKII sites (amino acid 205) has the largest entropy (1.24) among all of CKII's sites. The average entropy over MEME block 7 and 2 CKII sites is therefore higher than for any other block. MEME block 1 has a wider boxplot than the others, indicating more CKII sites in this block. (B) Average entropy of potential PKC phosphorylation site in the MEME blocks. MEME block 1 and 4 have zero entropy at all their PKC sites. The highest PKC entropy values were observed in MEME block 2 (amino acid 205) and MEME block 7 (amino acid 160) with 1.2 entropy values. MEME block 5, 7 and 11 are unusual in that very few of their PKC sites have zero entropy. MEME block 11 then 7 PKC sites have the highest average entropy. The width of the boxplots indicates that more PKC sites are observed in MEME sites 2, 3 and 7 respectively. (C) Average entropy of potential N-glycosylation site in the MEME blocks. MEME blocks 4 and 5 have zero entropy at all of their ASN sites. MEME block 2, 6 and 9 have nonzero entropy at the majority of their ASN sites. One of the ASN sites (amino acid 99) from MEME block 1 has the highest entropy (1.003) among all ASN sites. The width of the boxplots indicates that more N-glycosylation sites are observed in MEME sites 2 and 7 respectively (D) Average entropy of potential N-myristylation site in the MEME blocks. MEME blocks 1, 2, 4, and 9 have the majority of their myristylation sites possessing zero entropy. The highest myristylation sites entropy is at MEME block 9 and 7 (Amino acid 78 and 160 respectively) with an approximate entropy value of 1.2. MEME block 1 and 7 have more N-myristylation sites than any other block, although MEME block 2 also has a fairly large number of myristylation sites.