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Table 1 Virus evolution in animals infected with different variants.

From: Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses

     

Week 40

Week ~75

Infecting variant

Animal

Set point viral load1

(log10 copies/mL)

NtAb2 peak IC50

Diversity3

Mean Divergence4 (Range)

Mean dN/dS

Diversity3

Mean Divergence4(Range)

Mean dN/dS

"Early"

SIVMneCL8

J95155

3.2

759

0.40

0.2 (0–0.77)

0.16

0.52

0.52 (0–2.00)

1.07

  

F95274

3.8

1133

0.38

0.2 (0–0.51)

0.17

1.39

0.69 (0–1.35)

0.54

  

Average

3.5

946

0.39

0.20

0.16

0.96

0.60

0.81

"Intermediate"

SIVMne35wkSU

J95251

5.1

20

   

1.05

0.85 (0–1.48)

1.02

  

J96165

6.1

53

1.20

0.71 (0.38–1.21)

0.96

1.73

1.49 (0.90–3.01)

1.22

  

Average

5.6

36.5

1.20

0.71

0.91

1.39

1.17

1.12

"Late"

SIVMne170

F94393

6.9

1229

0.68

0.79 (0.51–1.17)

1.09

1.51

1.26 (0.13–2.00)

1.33

  

J94233

6.5

266

1.22

1.28 (0.89–1.57)

1.93

2.32

2.18 (0.38–3.28)

1.57

 

SIVMne027

J94454

7.0

1278

1.03

0.7 (0.13–1.16)

0.67

1.32

0.91 (0.51–1.43)

1.00

  

K94379

6.9

1517

1.27

1 (0.77–1.29)

1.16

1.59

1.4 (0.51–2.40)

1.07

  

Average

6.8

1072.5

1.05

0.94

1.21

1.69

1.44

1.24

  1. 1 Set point viral load[17]
  2. 2 NtAb peak IC50 = highest reciprocal dilution of plasma needed to neutralize 50% of virus infectivity
  3. 3 NtAb Diversity = average pairwise distance
  4. 4 Divergence = distance from infecting strain.
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Virology Journal

ISSN: 1743-422X