Antiviral effect of compounds in DRAW cells in function of time. (A) mAb (1:10 dilution), ENV (0.316 μg/ml) and mAb + ENV; (B) IFN-α (250 ng/ml) and IFN-γ (25 ng/ml). Controls consist of untreated cells. Cells were cultivated in 96-well plates at a density of 2.5 × 104 cells/well and virus yield was measured by plaque assay. Data are the mean result of duplicate samples from two independent experiments ± standard deviation; * P < 0.05 (unpaired Student's t test between untreated and compound-treated samples).