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Table 3 Determination of VN04-2 neutralization of H5N1-VLPs

From: Epitope characterization of the protective monoclonal antibody VN04-2 shows broadly neutralizing activity against highly pathogenic H5N1

 

H5N1-VLPa

Virusb

Virus

Neutralization (%)

HI assay

HI titer

A/Vietnam/1203/04

100

+

12,800

A/DK/Vietnam/376/05

100

+

ND

A/BhGs/Qing Hai/65/05

94

-

<

A/CK/Ivory Coast/1787/06

88

-

2001

A/Zhe Jiang/16/06

78

-

ND

A/DK/Guangzhou/20/05

99

+

6,4002

A/Indonesia/CDC597/06

99

-

ND

A/Indonesia/5/05

5

-

<3

A/CK/Indonesia/R60/05

0

-

ND

  1. aassays performed using humanized VN04-2 antibody at 2 ug/mL
  2. bassay data taken from Chen et al [11] performed using the mouse VN04-2 antibody (15A3) of unknown concentration; data obtained with virus exhibiting identical mutations relative to A/Vietnam/1203/04, 1MDk/JX/2136/05, 2MDk/JX/1653/, and 3Ck/Wajo/BBVM/05
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Virology Journal

ISSN: 1743-422X