Region
|
Patient Group
|
Samples
|
aIntrasample variability
|
Samples
|
bIntersample variability
|
---|
| | |
Ks
|
Ka
|
Ka/Ks
|
gd
| |
Ks
|
Ka
|
Ka/Ks
|
gd
|
---|
|
SVR
|
E
|
0.0195 ± 0.0141
|
0.0308 ± 0.0130
|
0.998
|
0.0283 ± 0.0095
| | | | | |
| |
B
|
0.0236 ± 0.0175
|
0.0225 ± 0.0115*
|
0.850
†
|
0.0233 ± 0.0091
|
B-B
|
0.0236 ± 0.0175
|
0.0225 ± 0.0115*
|
0.850
|
0.0233 ± 0.0091
|
| |
W1
|
0.0277 ± 0.0152
|
0.0302 ± 0.0100
|
1.067
‡
|
0.0302 ± 0.0087
|
B-W1
|
0.0293 ± 0.0160
|
0.0305 ± 0.0110
|
1.041
|
0.0305 ± 0.0095
|
| |
W2
|
0.0050 ± 0.0025
|
0.0375 ± 0.0155
|
2.700
|
0.0280 ± 0.0125
|
B-W2
|
0.0070 ± 0.0045
|
0.0370 ± 0.0205
|
7.300
|
0.0285 ± 0.0125
|
| |
W3/W4
|
0.0000 ± 0.0000
|
0.0135 ± 0.0075
|
NA
|
0.0095 ± 0.0045
|
B-W3/4
|
0.0015 ± 0.0015
|
0.0150 ± 0.0085
|
9.333
|
0.0110 ± 0.0055
|
HVR1
| | | | | | | | | | | |
|
NR
|
E
|
0.0292 ± 0.0185
|
0.0585 ± 0.0207
|
1.860
|
0.0492 ± 0.0145
| | | | | |
| |
B
|
0.0345 ± 0.0192
|
0.0802 ± 0.0227*
|
2.427
†
|
0.0667 ± 0.0185
|
B-B
|
0.0345 ± 0.0192
|
0.0802 ± 0.0227*
|
2.427
|
0.0667 ± 0.0185
|
| |
W1
|
0.0172 ± 0.0115
|
0.0507 ± 0.0175
|
2.033
‡
|
0.0412 ± 0.0135
|
B-W1
|
0.0218 ± 0.0125
|
0.0538 ± 0.0178
|
2.332
|
0.0432 ± 0.0130
|
| |
W2/4
|
0.0205 ± 0.0175
|
0.0320 ± 0.0135
|
1.574
|
0.0290 ± 0.0115
|
B-W2/4
|
0.0200 ± 0.0100
|
0.0325 ± 0.0135
|
1.648
|
0.0295 ± 0.0120
|
| |
L
|
0.0160 ± 0.0033
|
0.008 ± 0.0036
|
0.285
|
0.0106 ± 0.0043
|
B-L
|
0.0153 ± 0.008
|
0.0133 ± 0.0057
|
0.873
|
0.0137 ± 0.0047
|
Outside
| | | | | | | | | | | |
|
SVR
|
E
|
0.0106 ± 0.005
|
0.0023 ± 0.0015
|
0.216
|
0.0045 ± 0.0016
| | | | | |
| |
B
|
0.0130 ± 0.0061
|
0.0036 ± 0.0020
|
0.277
|
0.0061 ± 0.0023
|
B-B
|
0.0130 ± 0.0061
|
0.0036 ± 0.0020
|
0.277
|
0.0061 ± 0.0023
|
| |
W1
|
0.0052 ± 0.0022
|
0.0017 ± 0.0015
|
0.327
|
0.0027 ± 0.0012
|
B-W1
|
0.0050 ± 0.0020
|
0.0018 ± 0.0018
|
0.360
|
0.0025 ± 0.0013
|
| |
W2
|
0.0035 ± 0.0025
|
0.0025 ± 0.0015
|
0.714
|
0.0025 ± 0.0020
|
B-W2
|
0.0035 ± 0.0025
|
0.0025 ± 0.0020
|
0.714
|
0.0025 ± 0.0020
|
| |
W3/W4
|
0.0015 ± 0.0015
|
0.0010 ± 0.0010
|
0.667
|
0.0010 ± 0.0010
|
B-W3/4
|
0.0015 ± 0.0015
|
0.0010 ± 0.0010
|
0.667
|
0.0010 ± 0.0010
|
|
NR
|
E
|
0.0612 ± 0.0205
|
0.0042 ± 0.0025
|
0.068
|
0.0180 ± 0.0052
| | | | | |
| |
B
|
0.0280 ± 0.0115
|
0.0017 ± 0.0012
|
0.061
|
0.0085 ± 0.0032
|
B-B
|
0.0280 ± 0.0115
|
0.0017 ± 0.0012
|
0.061
|
0.0085 ± 0.0032
|
| |
W1
|
0.0132 ± 0.0085
|
0.0005 ± 0.0005
|
0.038
|
0.0040 ± 0.0022
|
B-W1
|
0.0148 ± 0.0090
|
0.0008 ± 0.0008
|
0.054
|
0.0043 ± 0.0025
|
| |
W2/4
|
0.0100 ± 0.0060
|
0.0015 ± 0.0010
|
0.150
|
0.0047 ± 0.0026
|
B-W2/4
|
0.0095 ± 0.0060
|
0.0015 ± 0.0010
|
0.158
|
0.0035 ± 0.0020
|
| |
L
|
0.0133 ± 0.0060
|
0.0006 ± 0.0006
|
0.045
|
0.0030 ± 0.0020
|
B-L
|
0.0140 ± 0.0057
|
0.0010 ± 0.0010
|
0.071
|
0.0043 ± 0.0020
|
- a The average number of nucleotide substitutions per nonsynonymous site and per synonymous site for all pairwise comparisons within each sampling point. b The average number of nucleotide substitutions per nonsynonymous site and per synonymous site for all pairwise comparisons for consensus of baseline for baseline sample (B-B) and follow-up samples (B-W1-2-3/4 and B-L). Ka/Ks indicate the ratio of nonsynonymous to synonymous nucleotide substitutions. All data represent mean ± SEM. The statistical significance of comparisons among individual samples or between the two groups of patients were analysed with non parametric Mann-Whitney U test.*, P = 0.05 for comparison between the two groups of patient. †, P = 0.01 for comparison between the two groups of patient. ‡, P = 0.05 for comparison between the two groups of patient.