Figure 2

Antiviral activity of Ribavirin and SCH 16 against JEV, WNV and Den-2 evaluated using the plaque reduction assay. Panel A: Represents the dose dependent reduction in JEV (yellow bars) and WNV (green bars) plaques obtained in PS cells with the standard antiviral agent Ribavirin (represented as bars). The X axis represents the various concentrations of the compound, Y' axis represents the percent reduction in plaques. The viability of cells is represented as line graph superimposed on the bar diagram on the Y axis. Panel B: Represents the dose dependent reduction in JEV (yellow bars) and WNV (green bars) plaques obtained in PS cells with the SCH 16 (represented as bars). The X axis represents the various concentrations of the compound, Y' axis represents the percent reduction in plaques. The viability of cells is represented as line graph superimposed on the bar diagram on the Y axis. Panel C: Represents the dose dependent reduction in Den-2 plaques (orange bars) obtained in BHK 21 cells with the Ribavirin (represented as bars). The X axis represents the various concentrations of the compound, Y' axis represents the percent reduction in plaques. The viability of cells is represented as line graph superimposed on the bar diagram on the Y axis. Panel D: Note that there was no reduction of in Den-2 plaques was obtained with the SCH 16 in BHK 21 cells. The X axis represents the various concentrations of the compound, Y' axis represents the percent reduction in plaques. The viability of cells is represented as line graph superimposed on the bar diagram on the Y axis.