Table 2 Activity of CDV Against Wild Type and CDV Resistant VV using a Plaque Reduction Assay in Human Foreskin Fibroblast and Vero Cells
From: Isolation and characterization of cidofovir resistant vaccinia viruses
Virus | HFF EC50 (μM)a | Vero EC50 (μM)a | Fold resistance over parental strain (HFF) | Fold resistance over parental strain (Vero) |
|---|---|---|---|---|
VV-WR, UAB | 28 ± 4.4 | 62 ± 12 | - | - |
VV-WR, Moyer | 18 ± 9.2 | 54 ± 2.9 | - | - |
CDVR 1A | 122 ± 69 | >317 ± 0 | 7 | >6 |
CDVR 15A | 98 ± 55 | 214 ± 17 | 5 | 4 |
CDVR 16A | 49 ± 4.5 | 199 ± 2.8 | 3 | 4 |