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Table 1 Antiviral activities of HIV inhibitors*

From: Closing two doors of viral entry: Intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1

Ab/fusion inhibitors IC50 ± SD (nM)
  NL-Bal (R5) NL4-3 (X4)
T-2635 2.6 ± 0.6 19.1 ± 7.3
IGF-1RmAb > 100 >100
IGF-1RmAb-FI** 421 ± 148 Not tested
CCR5mAb 0.9 ± 0.6 >100
BFFI (CCR5mAb-FI)** 0.03 ± 0.02 0.05 ± 0.0002
  1. * Results are from two or more independent experiments.
  2. ** Two T-2635 fusion inhibitors fused to the C-terminal ends of the heavy chain of an anti-IGF-1R mAb or anti-CCR5mAb through {G(Q)4}3-NN linker.