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Table 1 Antiviral activities of HIV inhibitors*

From: Closing two doors of viral entry: Intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1

Ab/fusion inhibitors

IC50 ± SD (nM)

 

NL-Bal (R5)

NL4-3 (X4)

T-2635

2.6 ± 0.6

19.1 ± 7.3

IGF-1RmAb

> 100

>100

IGF-1RmAb-FI**

421 ± 148

Not tested

CCR5mAb

0.9 ± 0.6

>100

BFFI (CCR5mAb-FI)**

0.03 ± 0.02

0.05 ± 0.0002

  1. * Results are from two or more independent experiments.
  2. ** Two T-2635 fusion inhibitors fused to the C-terminal ends of the heavy chain of an anti-IGF-1R mAb or anti-CCR5mAb through {G(Q)4}3-NN linker.
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Virology Journal

ISSN: 1743-422X