Table 1 a. Changes in HBsAg, HBeAg and HBV DNA prevalence with time in carriers detected between 1–4 years of age
From: Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia
Years after recruitment | ||||
|---|---|---|---|---|
Serological markers | 0 | 5 | 9 | 19 |
HBsAg sero positivity (%) | 68/68* (100) | 42/60 (70.0%) | 33/47 (70.2%) | 37/53 (70.0%) |
HBeAg seropositivity (%) | 57/68* (83.8%) | 25/42 (59.5%) | 12/33 (36.3%) | 5/53 (13.6%) |
HBV DNA positive | 62/62* (100%) | 15/24 (62.5%) | 20/39 (60.6%) | 30/34 (88.2%) |
b) | ||||
HBeAg positive carriers | ||||
0 | 5 | 9 | 19 | |
Those with detectable HBV DNA | 46/46 (100%) | 9/9 (100%) | 6/7 (85.7%) | 5/5 (100%) |
Those with viral load > 105 copies/mL) | 46/46 (100%) | 9/9 (100%) | 6/7 (85.7%) | 5/5 (100%) |
Geometric Mean HBV DNA (copies/mL) | 4.5 × 108 | 1.1 × 108 | 4.4 × 108 | 8.4 × 108 |
Median HBV DNA (copies/mL) | 1.0×109 | 3.5×108 | 1.5×109 | 5.0×108 |
IQR (copies/mL) | 5.0 × 108–2.0 × 09 | 5.0 × 107–6.5 × 108 | 5.5 × 108–6.5 × 109 | 4.0 × 108–2.5 × 109 |
c) | ||||
HBeAg negative carriers | ||||
0 | 5 | 9 | 19 | |
Those with detectable HBV DNA | 11/11 (100%) | 2/7 (28.6%) | 10/14 (71.4%) | 28/31 (90.3%) |
Those with high viral load (> 105 DNA copies/mL) | 2/11 (18.2%) | 1/7 (14.2%) | 1/14 (7.1%) | 3/31 (9.6%) |
Geometric mean HBV DNA (copies/mL) | 7.7 × 107 | 2.1 × 108 | 1.8 × 103 | 4.2 × 103 |
Median HBV DNA IQR (copies/mL) | 2.0 × 104 | 2.0 × 105 | 2.0 × 103 | 1.0 × 103 |
IQR (copies/mL) | 5.0 × 103–8.0 × 104 | **3.6 × 104–5.2 × 108 | 1.0 × 103–1.0 × 104 | 4.0x × 102-7.5 × 103 |