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Table 1 a. Changes in HBsAg, HBeAg and HBV DNA prevalence with time in carriers detected between 1–4 years of age

From: Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia

  Years after recruitment
Serological markers 0 5 9 19
HBsAg sero positivity (%) 68/68* (100) 42/60 (70.0%) 33/47 (70.2%) 37/53 (70.0%)
HBeAg seropositivity (%) 57/68* (83.8%) 25/42 (59.5%) 12/33 (36.3%) 5/53 (13.6%)
HBV DNA positive 62/62* (100%) 15/24 (62.5%) 20/39 (60.6%) 30/34 (88.2%)
b)     
HBeAg positive carriers
  0 5 9 19
Those with detectable HBV DNA 46/46 (100%) 9/9 (100%) 6/7 (85.7%) 5/5 (100%)
Those with viral load > 105 copies/mL) 46/46 (100%) 9/9 (100%) 6/7 (85.7%) 5/5 (100%)
Geometric Mean HBV DNA (copies/mL) 4.5 × 108 1.1 × 108 4.4 × 108 8.4 × 108
Median HBV DNA (copies/mL) 1.0×109 3.5×108 1.5×109 5.0×108
IQR (copies/mL) 5.0 × 108–2.0 × 09 5.0 × 107–6.5 × 108 5.5 × 108–6.5 × 109 4.0 × 108–2.5 × 109
c)     
HBeAg negative carriers
  0 5 9 19
Those with detectable HBV DNA 11/11 (100%) 2/7 (28.6%) 10/14 (71.4%) 28/31 (90.3%)
Those with high viral load (> 105 DNA copies/mL) 2/11 (18.2%) 1/7 (14.2%) 1/14 (7.1%) 3/31 (9.6%)
Geometric mean HBV DNA (copies/mL) 7.7 × 107 2.1 × 108 1.8 × 103 4.2 × 103
Median HBV DNA IQR (copies/mL) 2.0 × 104 2.0 × 105 2.0 × 103 1.0 × 103
IQR (copies/mL) 5.0 × 103–8.0 × 104 **3.6 × 104–5.2 × 108 1.0 × 103–1.0 × 104 4.0x × 102-7.5 × 103
  1. *The p-values for difference in prevalence between the first two time points are < 0.006 for HBsAg, < 0.001 for HBeAg and HBV DNA respectively.**One carrier who is HBeAg negative had high serum DNA level (5.2 × 108) at the second follow up point.