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Table 2 Susceptibility of VV Δ F2L-gfp to selected thymidine analogs and cidofovir.

From: Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine

Compound Name

VV Δ F2L-gfp (EC50, μM)a

VV WR wt (EC50, μM)

IDU

2.5 ± 0.9

2.4 ± 0.6

N-MCT

6.2 ± 3.5

12 ± 1.6

PFT3

2.0 ± 0.6

2.4 ± 0.4

PFT4

2.3 ± 1.1

2.5 ± 0.1

CDV

11 ± 4.2

10 ± 0.3

  1. a. Concentration required to reduce plaque formation by 50%. Values shown are the average of duplicate determinations with the standard deviations shown.
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Virology Journal

ISSN: 1743-422X