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Table 1 VV Δ F2L-gfp exhibits virulence characteristics that are similar to the parent virus.

From: Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine

Virus (PFU/mouse)a

Mortality

MDDb

 

Number

Percent

 

VV-WR, UAB

   

1.6 × 104

10/10

100

6.8 ± 0.8

1.6 × 103

3/10

30

8.3 ± 0.6

1.6 × 102

0/10

0

---

16

0/10

0

---

1.6

0/10

0

---

VV-WR, Turner

   

Stock 1.6 × 108

10/10

100

3.2 ± 0.4

1.6 × 107

10/10

100

3.9 ± 0.3

1.6 × 106

10/10

100

5.1 ± 0.3

1.6 × 105

10/10

100

6.2 ± 0.4

1.6 × 104

10/10

100

7.9 ± 1.0

VV Δ F2L-gfp

   

Stock 6 × 107

10/10

100

4.2 ± 0.4

6 × 106

10/10

100

4.7 ± 0.5

6 × 105

10/10

100

6.1 ± 0.6

6 × 104

10/10

100

7.1 ± 0.3

6 × 103

5/10

50

8.4 ± 0.5

  1. a. Anesthetized mice were inoculated intranasally with 40 μl of virus (20 μl/nostril).
  2. b. Mean day of death (MDD) is shown with the standard deviation.
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Virology Journal

ISSN: 1743-422X