Skip to main content
Figure 3 | Virology Journal

Figure 3

From: Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine

Figure 3

Model of dUTPase function in VV and a potential explanation of (N)-MCT hypersensitivity. Deletion of dUTPase is predicted to reduce intracellular pools of its dUMP product, which is converted to dTMP by thymidylate synthetase. This is significant since dTMP is predicted to compete with the monophosphate metabolite of N-MCT (N-MCT-MP) for subsequent anabolic reactions or as substrates for the target enzyme.

Back to article page

Virology Journal

ISSN: 1743-422X