Surface representation of the β-propeller domain of EED and protein-interacting regions. The binding residues of HIV-1 proteins are represented with the following colour code : yellow for the matrix protein (MA), red for integrase (IN). (A), Top view of the β-propeller showing the MA and IN binding sites laterally oriented. Note the absence of overlapping between the MA and IN binding sites, which form a continuous binding groove. (B), Side view of the β-propeller showing the MA+IN-binding groove on the lateral face, and the position of the EZH2 α-helical peptide 39–68 (represented in blue), bound to the EZH2-binding pocket facing downwards.