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Table 2 LACV is immunogenic in rhesus monkeys and can be detected in the lymph nodes.

From: La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys

     Homologous neutralizing antibody titer on indicated day (reciprocal PRNT60)c  
Virus and inoculation route Monkey # Temp. (°F)a Lymph node virus titersb -7 0 2 4 6 8 10 12 14 21 28 GMTd (Day 28)
Human/1978/clone (SQ) DB00   2.3 (day 12) <5 <5 <5 <5 <5 13 22 166 620 1465 2924 2186
  DB1Z    <5 <5 <5 <5 <5 24 137 126 332 679 1412  
  CL74    <5 <5 <5 <5 <5 <5 31 199 546 1370 1374  
  DBCV    <5 <5 <5 <5 <5 6 43 246 234 1684 4022  
Human/1978/clone (IM) DB9J    <5 <5 <5 <5 <5 <5 66 343 1011 603 1776 1906
  DB5C   1.4 (day 12) <5 <5 <5 <5 <5 <5 74 282 2382 7451 2714  
  DB7Y 103.2 (day 8)   <5 <5 <5 <5 <5 <5 15 37 230 4041 1628  
  DB3W 102.8 (day 6)   <5 <5 <5 <5 <5 <5 40 1643 460 2633 1688  
Mosquito/1978/clone (SQ) DB70    <5 <5 <5 <5 37 25 90 623 672 2325 3008 560
  DB8N   0.7 (day 12) <5 <5 <5 <5 12 29 72 194 161 211 663  
  CK74    <5 <5 <5 <5 <5 14 38 250 434 1023 399  
  CL2G    <5 <5 <5 <5 7 7 8 19 14 120 124  
Mosquito/1978/clone (IM) DBCZ    <5 <5 <5 <5 12 38 834 1325 3050 3695 4493 1691
  CL6E 103.1 (day 6) 0.7 (day 6) 5 6 6 <5 16 39 180 1960 2809 3875 960  
  DB0H    13 13 18 13 15 28 130 516 1566 1134 687  
  DA9F 102.9 (day -7) 0.7 (day 8) <5 <5 <5 <5 <5 11 94 1833 3189 3656 2762  
  1. a Rectal temperature collected at time of blood draw. Temperatures outside the normal range (98–102.7 F) indicated by day in parenthesis, normal values left blank.
  2. b Lymph nodes were collected on days 4, 6, 8, and 12 for virus titer and IHC staining. Viral titers are expressed as log10 PFU/half lymph node (day post inoculation). Viral antigen was not observed using IHC staining. Blank spaces indicate that virus was not detected in the lymph nodes. Lower limit of detection was .7 log10 PFU/tissue.
  3. c Limit of detection for neutralizing antibodies is 1:5 dilution.
  4. d Geometric mean neutralizing antibody titer.